Abstract Background The opioid crisis continues in full force. as physicians and caregivers are desperate for resources to help patients with opioid use and chronic pain disorders find safer and more accessible non-opioid tools. Main body The purpose of this article is to review the current state of the opioid epidemic; the shifting picture of cannabinoids; and the research. policy. https://www.roneverhart.com/Bearbrick-WALL-E-400/